It's unclear whether drinking pomegranate juice can lower cholesterol. But, it's thought that pomegranate juice could block or slow the buildup of cholesterol in your arteries when you have persistent, elevated levels of fats (lipids) in your blood and other risk factors associated with heart disease.
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Like many fruit juices, pomegranate juice contains antioxidants, especially polyphenols. What's more, pomegranate juice contains antioxidants at higher levels than do other fruit juices. Antioxidants are thought to provide several heart-protecting benefits, including reducing low-density lipoprotein (LDL, or "bad") cholesterol.
Pomegranate juice is generally safe to drink if certain facts are first considered. If you choose to drink pomegranate juice, check the label to be sure that you're drinking pure pomegranate juice, and not a mixture of juices that contains added sugar. The sugar adds more calories to the juice, which reduces its heart-health benefits.
As you should do with any herbal or dietary supplement, talk to your doctor about pomegranate juice before you start drinking it regularly as a supplement. Pomegranate juice may cause dangerous side effects when it interacts with certain prescription medications, such as the blood thinner warfarin (Coumadin) and angiotensin-converting enzyme (ACE) inhibitors, including captopril (Capoten), enalapril (Vasotec) and lisinopril (Prinivil, Zestril), and others.