If the signatures hold up through the verification process, voters in the nation's capital will face a November ballot initiative that would decriminalize psilocybin magic" mushrooms and other natural psychedelics like mescaline.
Activists are deemphasizing the recreational aspects of the drugs, focusing almost exclusively on the therapeutic and medical benefits as treatment for depression, trauma and addiction.
A growing body of work is looking at the effects of natural psychedelics to treat depression, trauma and addiction.
Maryland Republican Rep. Andy Harris, who sponsored the budget rider that blocked the 2014 marijuana initiative, has already indicated in press interviews that he plans to do the same if this new initiative passes.
The Democratic-controlled House approved a landmark D.C. statehood bill in June, but it faces insurmountable opposition in the Republican-held Senate.