For Marcus Mariota, the loss of confidence was the biggest blow.

Trey Lance flashed his big arm in a brief preseason stint for San Francisco with a 76-yard TD pass to speedy rookie Danny Gray that helped the 49ers beat the Green Bay Packers 28-21.

Dallas star rookie linebacker Micah Parsons and Cincinnati running back Joe Mixon were the latest big-name players added to the COVID-19 reserve list.

Cincinnati sacks leader Trey Hendrickson and three other starters are among five Bengals that have been placed on the COVID-19 reserve list.

Cam Newton followed Mac Jones along the sideline, holding his right hand up, waiting for the rookie quarterback to slap it after the No. 15 overall pick threw a touchdown in a preseason game Sunday night.

(AP Photo/Bill Kostroun)SANTA CLARA, Calif. – Jimmy Garoppolo’s early NFL education came going up against Bill Belichick’s complicated defense each day in practice with the New England Patriots. Now Garoppolo gets his first chance to go up against his former coach and team since being traded away to San Francisco nearly three years ago when the 49ers visit the Patriots on Sunday. “It set me up for everything here, made the transition a lot easier,” Garoppolo said about the work he did with the Patriots. I’m glad that it’s worked out for him and San Francisco. “I think that’s one of the most impressive things about Jimmy,” Shanahan said.

(AP Photo/Jed Jacobsohn)SANTA CLARA, Calif. – Carson Wentz hit Travis Fulgham on a 42-yard touchdown pass with 5:50 remaining to lift the Philadelphia Eagles to their first win of the season, 25-20 over the San Francisco 49ers on Sunday night. TAKE IT AWAYThe Eagles got their first defensive takeaway of the season thanks to a poor decision by Mullens. With the Niners in the red zone, Mullens threw a ball up for grabs while under pressure and Rodney McLeod came up with it. INJURY REPORTEagles: RT Lane Johnson left the game in the first half with an ankle injury but later returned. 49ers: DL Ezekiel Ansah left the game in the first half with an arm injury and didn’t return.