It was a costly victory for San Francisco, which was already short-handed before losing Garoppolo to an ankle injury and Mostert to an injured knee. Defensive end Nick Bosa and defensive tackle Solomon Thomas were both carted off the field two plays apart with left knee injuries in the first quarter. Bosa was carted off the field with a left knee injury. Two plays later, Thomas needed to be carted off — also with a left knee injury —after an 8-yard reception by Chris Hogan. The drive was prolonged by a roughing-the-passer penalty on Henry Anderson when the Jets appeared to have stopped San Francisco on third-and-8.