Wilson threw four more touchdown passes, two to Metcalf, and the Seahawks rebounded from their first loss of the season with a resounding 37-27 win over the San Francisco 49ers on Sunday.
Wilson and Metcalf tormented San Francisco and its banged up secondary as the top-scoring offense in the league continued to pile up points.
Wilson found rookie DeeJay Dallas on a 2-yard TD pass after San Francisco went three-and-out to open the second half for a 20-7 lead.
The momentum from two straight wins for San Francisco (4-4) evaporated in a hurry as more injuries continued to pile.
San Francisco played without starters Deebo Samuel, Jeff Wilson Jr., Kwon Alexander and safety Jaquiski Tartt.