Days after trading star running back Christian McCaffrey, the Carolina Panthers ran for a season-high 173 yards and rolled past Tom Brady and the Tampa Bay Buccaneers 21-3.

The Dallas Cowboys probably will be without four starters from their encouraging opener because of injuries and other issues.

(AP Photo/Brett Duke)NEW ORLEANS – Tom Brady was intercepted twice in his Tampa Bay debut, Alvin Kamara scored touchdowns running and receiving, and the New Orleans Saints beat the Buccaneers 34-23 on Sunday. Neither quarterback was statistically exceptional in this first-ever NFL game featuring two quarterbacks in their 40s. One exception was Saints safety and Players Coalition co-founder Malcolm Jenkins, who trotted to the Saints bench area after the anthem had finished. The Saints were flagged four times for 101 yards, with all of those calls occurring during the Bucs' first three scoring drives. Saints: Take part in the first NFL game played in Las Vegas, the Raiders' home opener on Monday night, Sept. 21.